COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM Running Title: Candidate genes in the Diabetes Prevention Program

1 The Biostatistics Center, George Washington University, Rockville, Maryland, USA; 2 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA; 3 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA; Departments of 4 Medicine and 10 Genetics, Harvard Medical School, Boston, Massachusetts, USA; 5 Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA; 6 Genetic Epidemiology & Clinical Research Group, Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University Hospital, Umeå, Sweden and Department of Clinical Sciences, Lund University, Malmö, Sweden; 7 Department of Medicine, Division of Endocrinology, Diabetes & Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA; 8 Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA; 9 Geriatrics Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA; and 11 Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA